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A Network Architecture for Bidirectional Neurovascular Coupling in Rat Whisker Barrel Cortex

The neurovascular coupling is mostly considered as a master-slave relationship between the neurons and the cerebral vessels: the neurons demand energy which the vessels supply in the form of glucose and oxygen. In the recent past both theoretical and …

Low-Dimensional Models of “Neuro-Glio-Vascular Unit” for Describing Neural Dynamics under Normal and Energy-Starved Conditions

The motivation of developing simple minimal models for neuro-glio-vascular (NGV) system arises from a recent modeling study elucidating the bidirectional information flow within the NGV system having 89 dynamic equations (1). While this was one of …

Vascular Dynamics Aid a Coupled Neurovascular Network Learn Sparse Independent Features: A Computational Model

Cerebral vascular dynamics are generally thought to be controlled by neural activity in a unidirectional fashion. However, both computational modeling and experimental evidence point to the feedback effects of vascular dynamics on neural activity. …

A Computational Model of Neuro-Glio-Vascular Loop Interactions

We present a computational, biophysical model of neuron-astrocyte-vessel interaction. Unlike other cells, neurons convey “hunger” signals to the vascular network via an intervening layer of glial cells (astrocytes); vessels dilate and release glucose …

A Model of Indispensability of a Large Glial Layer in Cerebrovascular Circulation

We formulate the problem of oxygen delivery to neural tissue as a problem of association. Input to a pool of neurons in one brain area must be matched in space and time with metabolic inputs from the vascular network via the glial network. We thus …